Senior Faculty Fellow, Professor of Chemistry and
The Barnett Institute, 341 Mugar
Dr. Giese’s research is in the detection and identification of trace analytes such as genotoxic chemicals, DNA adducts, environmental contaminants, steroids, and bio-active peptides by mass spectrometry. The work combines analytical chemistry, organic chemistry, and biochemistry to advance the reagents and techniques available for sample reparation. Novel tags are developed for derivatization to increase analyte response and selectivity.
Shao, G., Kautz, R., Peng, S., Cui, G., Giese, R. W. (2007) Calibration by NMR for quantitative analysis:
Yong. L. C., Schulte, P. A., Kao, C-K., Giese, R. W., Boeniger, M. F., Strauss, G. H.S., Petersen, M. R., Wiencke, J. K. (2007) DNA Adducts in Granulocytes of Hospital Workers Exposed to Ethylene Oxide, Am. J. Ind. Med., 50, 293-302.09.
Gao, H., Wu, B., Giese, R. Zhu, A. (2007) Xom interacts with and stimulates transcriptional activity of LEF1/TCFs: implications for ventral cell fate determination during vertebrate embryogenesis, Cell Res. 17, 345-356.
Wang, Y., Cui, G., Zhao, M., Yang, J., Wang, C. Giese, R. W., Peng, S. (2008) Bioassay-directed purification of an acidic phospholipase A2 from Agkistrodon halys pallas venom, Toxicon 51, 1131-1139.
Wang, P., Li, G., Gao, J., Zhang, X., Giese, R. W. Intensified Neutral Loss Tags and Use thereof in Mass Spectrometry, U.S. Patent 7,556,969 July 7, 2009.
Shao, G., Kautz, R., Peng, S., Cui, G., Giese, R. W., "Calibration by NMR for quantitative analysis: p-Toluenesulfonic acid as a reference substance", J. Chromatogr. A, 1138, 305-308 (2007).
Murugaiah, V., Naim, A., Peng, S., Cui, G., Giese, R. W., "4-(4'-Methyltetrafluorophenyl)-2,3,5,6-tetrafluorobenzyl bromide: A new electrophoric derivatizing reagent", J. Chromatogr113. A, 4, 338-340 (2006).
Shimelis, O., Giese, R. W., "Nuclease P1 digestion/high-performance liquid chromatography, a practical method for DNA quantitation", J. Chromatogr. A., 1117, 132-136 (2006).
Pashkova, A., Chen, H., Rejtar, T., Zang, X., Giese, R., Andreev, V., Moskovets, E. Karger, Barry L. "Coumarin Tags for Improved Analysis of Peptides by MALDI-TOF MS and MS/MS. II. Alexa Fluor 350 Tag for Increased Peptide and Protein Identification by LC-MALDI-TOF/TOF MS", Anal. Chem., 4(1), 129-135 (2005).