Collaborative Research Agreements
CARA establishes Collaborative Research Agreements (CRA), which
are intended to be multi-year and involve funding for dedicated equipment and
staff. In return, the sponsor
receives access to CARA resources and knowledge.
The intention of a CRA is to enter into a significant research/technology development effort to solve some of the major problems and challenges facing industrial and government partners (translational science). Thus, CRA's are expected to be three years in duration, which often will involve proof-of-concept for the first year, and result in significant invention, training, exchange of personnel and in general generate results which have a significant positive impact on the drug development of the industrial partner and thus a significant return on investment. In many cases, the research, which is generally published, can also have a broad impact on biotechnology as a whole.
Examples of CRA type agreements have been in the areas of biopharmaceutical process optimization, validation of potency models using proteomics analysis of expression pathways and the determination of critical quality attributes and structure function relationships of complex glycoproteins.