“The Barnett Institute has an impressive history of anticipating where science and societal needs intersect, and then producing high-impact solutions to meet those needs.” (Joseph E. Aoun, President, Northeastern University)
The Barnett Institute’s expertise in separating and analyzing chemical compounds through such techniques as capillary electrophoresis, high-pressure liquid chromatography, and mass spectrometry is recognized worldwide.
It’s also a premier center for cutting-edge research and advanced analytical-chemistry training for biomedical applications.
The Barnett Institute has contributed many significant technologies that have become standard in bioanalysis.
- Discovery of biomarkers for breast, cervical, and lung cancer.
- Antibody-based technologies for biomarker discovery and diagnostics.
- Human Proteome Organization (HUPO) Reference Lab.
- Editor in Chief, Journal of Proteome Research (ACS).
Comprehensive Analysis of Proteins
- Extended Range Proteomic Analysis: high sequence coverage of large proteins, including characterization of glycosylation and phosphorylation.
- Multiple Lectin Affinity Chromatography (MLAC): Rapid isolation of glycoproteins, the most biomedically relevant class of proteins.
- CE-MS analysis of protein microheterogeneity.
- Protein solution structure and dynamics by hydrogen-deuterium exchange MS.
- Post-translational modifications of proteins and DNA by biochemical tagging and mass spectrometry.
- Microscale LC-MS-NMR for metabolites and natural products.
- Reagents and methods for detection of DNA adducts. Environmental Cancer Research Program.
- Genome Sequencing: Key technologies used to sequence the human genome: microcapillary gel electrophoresis and linear polymer sieving matrices.
- HPLC: Major contributions to the development and acceptance of liquid chromatography, currently a multi-billion dollar industry.
- Capillary Electrophoresis: Screening of natural product extracts for new therapeutic compounds using capillary electrophoresis. Detection of rare single nucleotide mutations in DNA pooled from populations.
- LC-MS: Electrospray mass spectrometry from a microfluidic device.