Studies from the Lewis lab featured in the media

 

  • Mulcahy, L.R., Burns, J.L., Lory, S., and Lewis, K. (2010). Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis. J. Bacteriol. 192:6191–6199.

Microbe (2011) Persister Cells Fingered in Chronic CF. (Feature).

 

  • Anthony D’Onofrio, Jason M. Crawford, Eric J. Stewart, Kathrin Witt, Ekaterina Gavrish, Slava Epstein, Jon Clardy, Kim Lewis (2010) Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria. Chemistry & Biology 17(3)256-264.

    Discover Magazine (2010) Luring Out the Missing Biosphere. Carl Zimmer.

    Faculty of 1000 Biology (2010), A “Must read” by Harald Labischinski.

    Microbe Feature (2010), by Carol Potera, and Podcast.

 

  • Dörr T, Vulic M, Lewis K (2010) Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. PLoS Biol 8(2): e1000317.

    Faculty of 1000 Biology (2010) Review. Daniel Madar and Uri Alon.

    Boston Globe (2010) Outwitting germs that never say die. Carolyn Y. Johnson.

 

  • Schumacher, M.A., Piro, K.M., Xu, W., Hansen, S., Lewis, K., and Brennan, R.G. 2009. Molecular mechanisms of HipA mediated multidrug tolerance and its neutralization by HipB. Science 323:396-401.

    Educational video: http://www.3dciencia.com/.

 

  • Hansen, S. Lewis, K. Vulic, M. (2008) Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli. Antimicrob Agents Chemother. 52(9):2716-26.

    Microbe, Current Topics. (2008) Genes Underlying Bacterial “Persister Cells” Identified. 3:399-400.

 

  • Belofsky, G., Carreno, R., Lewis, K., Ball, A., Casadei, G., and Tegos, G.P. (2006) Metabolites of the ‘Smoke Tree’ Dalea spinosa Potentiate Antibiotic Activity against Multi-Drug Resistant (MDR) Staphylococcus aureus. J. Nat. Prod. Chem. 69:261-4.

    American Society of Pharmacognosy (ASP) Newsletter, Clearing the Air on the Smoke Tree, Vol. 42(2) 2006.

 

  • Moy, T.I., Ball, A.R., Anklesaria, Z., Casadei, G., Lewis, K., and Ausubel F.M. (2006) From the Cover: Identification of novel antimicrobials using a live-animal infection model. Proc. Natl. Acad. Sci. U S A. 103:10414-9.

    PNAS In the News. Identification of novel antimicrobials using a live-animal infection model, July 2006.

    Nature Reviews: Microbiology, Research Highlights. Anti-infectives Worming a way to better drugs August 2006.

    Nature Biotechnology, Research Highlights. The worm turns for antimicrobial discovery. September 2006.

 

  • Kaeberlin, T., Lewis, K., and Epstein, S. S. (2002) Isolating “uncultivable” microorganisms in pure culture using a simulated natural environment. Science 296:1127-1129.

    Science (News) 296:550 (2002)

 

  • Lin, J., Tiller, J.C., Lee, S.B., Lewis, K., and Klibanov, A.M. (2002) Insights into bactericidal action of surface-attached poly(vinyl-N-hexylpyridinium) chains. Biotechnol. Lett. 24:801-805.

    Chem. Engineer. News (2002) 80:22. Surface Designed to Kill Bacteria.

 

  • Spoering, A. L. and Lewis, K. (2001) Biofilms and Planktonic Cells of Pseudomonas aeruginosa Have Similar Resistance to Killing by Antimicrobials. Journal of Bacteriology 183:6746-6751

    ASM News Journal Highlights. Persister Cells Responsible for Biofilms’ Antimicrobial Resistance. January 2002.

 

  • Tiller, J.C., Liao, C.J., Lewis, K., and Klibanov, A.M. (2001). Designing surfaces that kill bacteria on contact. Proc. Natl. Acad. Sci. U S A. 22:5981-5985.

    Chem. Engineer. News (2001) 79:13. Designed Surface Kills Bacteria.

    Chem. Engineer. News (2001) 79:50. Chemistry highlights 2001. Science (News) 159(21):325 (2001)

    Technology Review (MIT) 104:19 (2001)

    Lewis interview with NPR: http://www.npr.org/templates/story/story.php?storyId=1123328

 

  • Stermitz, F.R., Lorenz, P., Tawar, J.N., Zenewicz, L., and Lewis, K. (2000). Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor. Proc. Natl. Acad. Sci. USA 97:1433-1437.

    Chem. Engineer. News (2000). 78 (8):6-7. Plant may hold key to ultimate antibiotic.

    Chem. Engineer. News (2000). 78 (51):24-31. Chemistry highlights 2000.

Other Publications

  • Ekaterina Gavrish, Clarissa S. Sit, Shugeng Cao, Olga Kandror, Amy Spoering, Aaron Peoples, Losee Ling, Ashley Fetterman, Dallas Hughes, Anthony Bissell, Heather Torrey, Tatos Akopian, Andreas Mueller, Slava Epstein, Alfred Goldberg, Jon Clardy, Kim Lewis (2014) Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2. Chemistry & Biology. Apr 24;21(4):509-18. [Link]
  • Keren, I., Wu, Y., Innocencio, J., Mulcahy, L., and Lewis, K. (2013) Killing by bactericidal antibiotics does not depend on reactive oxygen species. Science. 339: 1213-1216. [Link]
  • Sonja Hansen, Marin Vulic, Jungki Min, Tien-Jui Yen, Maria A. Schumacher, Richard G. Brennan, Kim Lewis (2012) Regulation of theEscherichia coli hipBA toxin-antitoxin system by proteolysis. PLoS ONE. 7(6):e39185. [PDF]
  • Kim Lewis (2012) Antibiotics: Recover the lost art of drug discovery. Nature. 485:439-440. [PDF]
  • Keren I, Minami S, Rubin E, and Kim Lewis (2011) Characterization and transcriptome analysis of Mycobacterium tuberculosis. mBio. 2(3):e00100-11. [PDF]
  • Lawrence R. Mulcahy, Jane L. Burns, Stephen Lory, and Kim Lewis (2010) Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis. J. Bacteriol. 192(23)6191-99. [PDF]
  • Kim Lewis (2010) Persister cells. Annu. Rev. Microbiol. 64:357-372. [PDF]
  • Kim Lewis, Slava Epstein, Anthony D’Onofrio and Losee L Ling (2010) Uncultured microorganisms as a source of secondary metabolites. J. Antibiot. 63(8):468-76. [PDF]
  • Anthony D’Onofrio, Jason M. Crawford, Eric J. Stewart, Kathrin Witt, Ekaterina Gavrish, Slava Epstein, Jon Clardy, Kim Lewis (2010) Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chemistry & Biology. 17(3)256-264. [PDF]
  • Dörr T, Vulic M, Lewis K (2010) Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. PloS Biology. 8(2): e1000317. [PDF]
  • Michael D. LaFleur, Qingguo Qi, and Kim Lewis. (2010) Patients with long-term oral carriage harbor high-persister mutants of C. albicans. Antimicrob. Agents Chemother. 54(1): 39–44. [PDF]
  • Dörr T, Lewis K, Vulic M, (2009) SOS response induces persistence to fluoroquinolones in Escherichia coli. PLoS Genet 5(12):e1000760. [PDF]