ADC Home | Northeastern University
The Antimicrobial Discovery Center(ADC) is a molecular microbiology group at Northeastern University studying bacterial persister cells, drug discovery, unculturable microorganisms, and Mycobacterium tuberculosis.

Selected Publications

Sonja Hansen, Marin Vulic, Jungki Min, Tien-Jui Yen, Maria A. Schumacher, Richard G. Brennan, Kim Lewis (2012) Regulation of the Escherichia coli hipBA toxin-antitoxin system by proteolysis. PLoS ONE. 7(6):e39185. [PDF]

Kim Lewis (2012) Antibiotics: Recover the lost art of drug discovery. Nature. 485:439-440. [PDF]

Keren I, Minami S, Rubin E, and Kim Lewis (2011) Characterization and transcriptome analysis of Mycobacterium tuberculosis. mBio. 2(3):e00100-11. [PDF]

Lawrence R. Mulcahy, Jane L. Burns, Stephen Lory, and Kim Lewis (2010) Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis. J. Bacteriol. 192(23)6191-99. [PDF]

Kim Lewis (2010) Persister cells. Annu. Rev. Microbiol. 64:357-372. [PDF]

Kim Lewis, Slava Epstein, Anthony D'Onofrio and Losee L Ling (2010) Uncultured microorganisms as a source of secondary metabolites. J. Antibiot. 63(8):468-76. [PDF]

Anthony D'Onofrio, Jason M. Crawford, Eric J. Stewart, Kathrin Witt, Ekaterina Gavrish, Slava Epstein, Jon Clardy, Kim Lewis (2010) Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chemistry & Biology. 17(3)256-264. [PDF]

Dörr T, Vulic M, Lewis K (2010) Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. PloS Biology. 8(2): e1000317. [PDF]

Michael D. LaFleur, Qingguo Qi, and Kim Lewis. (2010) Patients with long-term oral carriage harbor high-persister mutants of C. albicans. Antimicrob. Agents Chemother. 54(1): 39–44. [PDF]

Dörr T, Lewis K, Vulic M, (2009) SOS response induces persistence to fluoroquinolones in Escherichia coli. PLoS Genet 5(12):e1000760. [PDF]