Our laboratory studies persister cells responsible for tolerance to antibiotics, uncultured bacteria of the environment and the microbiome, and works on drug discovery.


Kim Lewis, Ph.D.



Room 306C Mugar Life Sciences Building
Northeastern University
360 Huntington Ave
Boston, MA 02115

Email: k.lewis@neu.edu
Tel: 617.373.8238


Selected Publications

      • Schumacher, M., Balani, P., Min, J., Chinnam, N., Hansen, S., Vulić, M., Lewis, K.*, Brennan, R.* (2015) HipAB-promoter structures reveal basis of heritable multidrug tolerance. Nature. 524:59-64. (*co-corresponding authors)
      • Sharma, B., Brown, A., Matluck, N., Hu, L., Lewis, K. (2015) Borrelia burgdorferi, the causative agent of Lyme disease, forms drug-tolerant persister cells. Antimicrob Agents Chemother. 59:4616-24.
      • Shan, Y., Lazinski, D., Rowe, S., Camilli, A., Lewis, K. (2015) Genetic basis of persister tolerance to aminoglycosides in Escherichia coli. mBio. e00078-15.
      • Ling, L., Schneider, T., Peoples, A., Spoering, A., Engels, I., Conlon, B., Mueller, A., Schäberle, T., Hughes, D., Epstein, S., Jones, M., Lazarides, L., Steadman, V., Cohen, D., Felix C., Fetterman, K., Millett, W., Nitti, A.,Zullo, A., Chen, C., and Lewis, K. (2015) A novel antibiotic kills pathogens without detectable resistance. Nature. 517:455-459.
      • Gavrish, E., C. S. Sit, S. Cao, O. Kandror, A. Spoering, A. Peoples, L. Ling, A. Fetterman, D. Hughes, A. Bissell, H. Torrey, T. Akopian, A. Mueller, S. Epstein, A. Goldberg, J. Clardy and K. Lewis. (2014) Lassomycin, a ribosomally synthesized cyclic peptide, kills Mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chem Biol. 21: 509-518.
      • Conlon, B., Nakayasu, E., Fleck, L., LaFleur, M., Isabella, V., Coleman, K., Leonard, S., Smith, R., Adkins, J. and Lewis, K. (2013) Activated ClpP kills persisters and eradicates a chronic biofilm infection. Nature. 503(7476):365-370.
      • Keren, I., Wu, Y., Innocencio, J., Mulcahy, L., and Lewis, K. (2013) Killing by bactericidal antibiotics does not depend on reactive oxygen species. Science. 339:1213-1216.
      • Keren, I., Minami, S., Rubin, E. and Lewis, K. (2011) Characterization and transcriptome analysis of Mycobacterium tuberculosis persisters. mBio. e00100-11.
      • Dörr, T., Vulić, M., Lewis, K. (2010) Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli. PLoS Biology. e1000317.
      • D’Onofrio, A., Crawford, J., Stewart, E., Witt, K., Gavrish, E., Epstein, S., Clardy, J., Lewis, K. (2010) Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria. Chemistry & Biology. 17(3):254-264.